Cadence: the Menopause Programme

The hot-flush herb on most labels doesn't beat a placebo.

When researchers pooled the trials, soy extract, black cohosh and red clover, the ones this shelf is built on, mostly didn't separate from a sugar pill for hot flushes. A placebo already cuts flushes by a quarter to a half in these studies, and most of these herbs don't do better than that. Sage is the one women ask us about most, and it gets its own answer further down.

So we started somewhere less crowded: the ingredients that do hold up. Genistein at the dose that worked. Ashwagandha and saffron, which have real trials in menopausal women for sleep and mood. Creatine, which most brands here haven't touched, for muscle and memory. We tell you the number, and we tell you where the number is small.

What the evidence supports

✓Genistein for hot flushes, at 54 mg, the studied dose
✓Ashwagandha & saffron for sleep, stress and mood, trialled in menopausal women
✓Creatine for muscle strength and memory
✓Vitamin D where you're deficient, which about half of Indian women are
–Black cohosh, red clover, sage: we left them out, and we say why

One programme, built around where you are.

You don't need all four. Tell us what's loudest right now, hot flushes, sleep, your body changing, and we'll point you to the ones that fit. Most women start with two and add from there.

01

Tell us what's loudest

A two-minute set of questions about your symptoms and where you are in the transition. No sign-in.

02

Get your short list

Two or three products that fit what you're feeling, with the studied dose and the honest limit for each.

03

Give it about 12 weeks

Most of these work over two to twelve weeks, not overnight. Your monthly refill keeps the dose steady.

Take the 2-minute quiz

The four.

Every active is at the dose used in the research it comes from, capped where Indian rules require it, and printed here.

Vegetarian

Cool

Hot flushes & night sweats

A daily capsule of genistein, the one soy compound the reviews flagged as working, at the amount that eased flushes in a two-year trial.

Genistein from genistein-rich soy isoflavones54 mg

Honest limit: it eases how often flushes come. It won't switch them off, and it isn't hormone therapy.

How to take it: One capsule daily with water. Give it about 8 to 12 weeks, and don't take more than one a day.

Before you start: contains soy isoflavones, a phytoestrogen. If you have a history of a hormone-sensitive cancer such as breast cancer, or you take tamoxifen or other hormonal medication, talk to your doctor first. Not for use in pregnancy or breastfeeding.

A stronger version, with S-equol, is in the works for women whose bodies can't make it themselves (about half do not).

₹899₹53930 capsules · daily

Vegan-suitable

Rest

Sleep, stress & low mood

An evening drink for the wired-tired-low nights. Four things that each have their own trial, in one sachet.

Ashwagandha KSM-66 root, ≥5% withanolides600 mg
Saffron ≥3.5% Lepticrosalides30 mg
Magnesium bisglycinate200 mg
L-theanine200 mg

Honest limit: it supports rest and lifts a low, stressed mood. It isn't a sleeping pill, and it doesn't treat clinical depression or anxiety.

How to take it: One sachet into 200 to 250 ml of warm or cold water, stirred well and drunk promptly, in the evening. Give it two to eight weeks.

Before you start: contains ashwagandha. Not for you if you have liver disease or a thyroid disorder, or take sedatives or thyroid medication, unless your doctor says otherwise. If you have a history of a hormone-sensitive cancer, check first. Stop taking it and see a doctor if you notice signs of a liver problem. It can make you drowsy, so take it in the evening and not with alcohol. Not for use in pregnancy or breastfeeding.

₹1,299₹77930 evening sachets

Vegetarian

Strength

Muscle, memory & bone

Creatine is the quiet one here, well studied for strength and memory in older women, and barely used on this shelf. Alongside the nutrients your bones lean on.

Creatine monohydrate3 g
Calcium citrate250 mg
Vitamin D3600 IU
Vitamin K2 MK-755 µg

Honest limit: it supports strength and memory, and gives bone the nutrients it needs, best with resistance or weight-bearing exercise. It doesn't prevent osteoporosis or falls.

How to take it: One sachet into 200 to 250 ml of water, or a drink of your choice. Mix well, once daily. It works best on the days you also train.

Before you start: contains vitamin K2, which works against warfarin and other blood thinners, so clear it with your doctor if you take one. If you have kidney disease, ask your doctor before taking creatine. If you are pregnant or breastfeeding, check first.

₹999₹59930 sachets · daily

Contains fish

Renew

Skin hydration & elasticity

Marine collagen at the dose the skin trials used, with the vitamin C your body needs to build its own. Marine, so it stays clear of beef.

Marine collagen peptides5 g
Vitamin C65 mg

Honest limit: it supports skin hydration and stretch over a few months. It won't remove wrinkles.

How to take it: One sachet into 200 to 250 ml of water or juice. Stir until it dissolves, once daily. Give it about 8 to 12 weeks.

Before you start: this one is not vegetarian. It is made from marine collagen, so it contains fish. Do not take it if you are allergic to fish. If you are pregnant or breastfeeding, check with your doctor first.

₹1,099₹65930 sachets · daily

Prices are indicative and settle at our first production run. Reserve pricing shown is 40% off for early sign-ups.

Menopause isn't one moment. Where are you?

The transition takes years, and what troubles you shifts as it goes. You don't have to know your exact stage, pick what sounds like you.

Perimenopause

Still getting periods, but they've changed

Cycles that skip or flood, mood that swings like it did before a period, the first hot flushes, nights that don't hold. Two things you already know from Cadence fit here too.

RestCoolEase · mood Restore · iron

Around your last period

Flushes and sleep at their loudest

Hot flushes and night sweats often peak here, and the broken sleep and low mood ride along with them. This is where most women start with two.

CoolRest

Postmenopause

A year or more since your last period

Flushes can linger for years, and the quieter changes matter now, bone, muscle, memory, skin. This is when Strength earns its place.

StrengthCoolRenew · skinBalance · metabolic

Why some familiar names aren't here.

A lot of menopause products lead with black cohosh, red clover, or sage. They carry long histories, and many women feel real comfort from them. We hold ourselves to one rule: an ingredient goes in only when strong modern research shows it helps the exact thing the product is for. Here is where each one falls short, so you can judge our reasoning rather than take our word for it.

For these, that evidence isn't there yet, so we left them out. If it grows, we'll gladly welcome them in.

Black cohosh and red cloverBoth have been put through placebo-controlled trials, and neither reliably beat the placebo for hot flushes. Black cohosh also carries a rare liver signal.
Sage, the one worth explaining properlySearch for sage and menopause and you will find studies that look encouraging, so this deserves a straight answer rather than a shrug. The study nearly every sage product points to gave sage to everyone who took part, with no placebo group to compare against. That matters more here than almost anywhere else, because a sugar pill on its own cuts hot flushes by a quarter to a half. When everyone in a study improves and nobody was given a placebo, you cannot tell whether the sage did it. Pool the controlled trials that do exist and the result does not reach significance, which means the effect could be real or could be nothing. So our position is not that sage fails. It is that nobody has shown it works yet, and we would rather not charge you for an ingredient on that basis. If a proper placebo-controlled trial changes the picture, we will put it in and say so.
MelatoninIt's sold everywhere for sleep, but in trials of menopausal women it didn't improve sleep over placebo.
BiotinNo real benefit for hair or skin unless you're deficient, and it can throw off common blood tests, including one for heart attacks.

Reserve now, save 40%.

We're opening soon. Leave your email or phone, and we'll set aside 40% off for you, our way of thanking the people who came early. We won't be able to offer it at launch.

40% off, only for early friends
No payment today
We'll tell you the day we open

The Kit, all three core products, comes to ₹3,197₹1,899 reserved. Tap The Kit below to reserve all three, or pick just what you need.

You're on the list.

Your 40% off is saved. We'll reach out the day we open. Thank you for being here early.

Questions worth asking.

No. These are food supplements, not hormones and not a replacement for hormone therapy. If your symptoms are severe, HRT is the most effective option and worth discussing with your doctor. These sit alongside that conversation, they don't stand in for it.

Not without your doctor's go-ahead. Cool contains soy genistein, a plant compound with mild estrogen-like activity, so anyone with a history of a hormone-sensitive cancer, or on tamoxifen, should check first. Rest, Strength and Renew don't contain phytoestrogens, but please still tell your doctor what you're taking.

Not overnight. Sleep and mood tend to shift over two to eight weeks, hot flushes and skin over eight to twelve. Muscle and memory build with steady use and exercise. If a product promised you instant relief, that would be the thing to distrust.

No, and we'd rather you didn't buy what you don't need. Most women start with the one or two that match what's loudest, hot flushes, or sleep, and add later. The short questionnaire points you to the right start.

Yes. Perimenopause, when cycles are still coming but changing, is where a lot of this begins. Rest and Cool fit early, and two products you may already know from Cadence, Ease for the mood swings and Restore for heavy bleeding, carry straight over.

Cool, Rest and Strength are all vegetarian, and Rest is vegan-suitable too. Renew is the exception: it's made from marine collagen, so it contains fish. We use marine rather than beef-derived collagen on purpose. It's clearly marked on the pack.

600 IU is the daily requirement for adults in India, and Strength is built to cover that day to day, alongside the calcium and K2 that bone actually uses. It isn't a correction dose. If a blood test shows you're properly deficient, and about half of Indian women are, you may need more for a while, and that is your doctor's call rather than a supplement's.

The menopause years, met with the doses the research actually used.